The disorder is clinically distinctive and relatively homogeneous, although seizure severity and specific frontal lobe seizure manifestations vary within families (Hayman et al., 1997). The condition usually persists through adult life (Scheffer et al. The disorder may be misdiagnosed as night terrors, nightmares, hysteria, or paroxysmal nocturnal dystonia. It is characterized by childhood onset of frequent violent and brief motor seizures occurring at night. Nocturnal frontal lobe seizures are also observed in some patients with familial focal epilepsy with variable foci (FFEVF 604364), caused by mutation in the DEPDC5 gene ( 614191) on chromosome 22q12.Īutosomal dominant nocturnal frontal lobe epilepsy (ENFL, ADNFLE) is a partial epilepsy with frontal lobe seizure semiology. See also ENFL2 ( 603204), which maps to chromosome 15q24 ENF元 ( 605375), caused by mutation in the CHRNB2 gene ( 118507) on chromosome 1q21 ENFL4 ( 610353), caused by mutation in the CHRNA2 gene ( 118502) on chromosome 8p21 and ENFL5 ( 615005), caused by mutation in the KCNT1 gene ( 608167) on chromosome 9q34. Nocturnal frontal lobe epilepsy is a genetically heterogeneous condition. Genetic Heterogeneity of Nocturnal Frontal Lobe Epilepsy The disorder is clinically distinctive and relatively homogeneous, although seizure severity and specific frontal lobe seizure manifestations vary within families ( Hayman et al., 1997). Autosomal dominant nocturnal frontal lobe epilepsy (ENFL, ADNFLE) is a partial epilepsy with frontal lobe seizure semiology.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |